|
|
taurochenodeoxycholate + H2O <=> chenodeoxycholic_acid + taurine
|
3.5.1.24
choloylglycine hydrolase
3.5.1.74
chenodeoxycholoyltaurine hydrolase
|
–
–
|
MK
|
| |
BRENDA:
BR22711
KEGG:
R03977
MetaCyc:
CHENODEOXYCHOLOYLTAURINE-HYDROLASE-RXN
|
|
|
|
glycochenodeoxycholic_acid + H2O <=> chenodeoxycholic_acid + glycine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
MK
|
| |
BRENDA:
BS140405
KEGG:
R03975
MetaCyc:
RXN-17388
|
|
|
|
chenodeoxycholic_acid + NADP+ <=> 7alpha-Hydroxy-3-oxo-5beta-cholan-24-oic_acid + NADPH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.392
3alpha-hydroxycholanate dehydrogenase (NADP+)
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
–
|
|
| |
BRENDA:
BS187020
MetaCyc:
RXN-17413
|
|
|
|
chenodeoxycholic_acid + NAD+ <=> 7alpha-Hydroxy-3-oxo-5beta-cholan-24-oic_acid + NADH + H+
|
1.1.1.112
indanol dehydrogenase
1.1.1.395
3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
1.1.1.52
3alpha-hydroxycholanate dehydrogenase (NAD+)
|
–
–
–
–
|
|
| |
BRENDA:
BS187020-a
MetaCyc:
RXN-17410
|
|
|
|
chenodeoxycholic_acid + NAD+ <=> 7-ketolithocholic_acid + NADH + H+
|
1.1.1.159
7alpha-hydroxysteroid dehydrogenase
|
–
|
M
|
| |
BRENDA:
BS187367-a
MetaCyc:
RXN-16033
SABIO-RK:
9929
|
|
|
|
ATP + chenodeoxycholic_acid + CoA <=> AMP + diphosphate + chenodeoxycholoyl-CoA
|
6.2.1.7
cholate---CoA ligase
|
–
|
MK
|
| |
BRENDA:
BS345
KEGG:
R08743
MetaCyc:
RXN-17398
|
|
|
|
chenodeoxycholoyl-CoA + H2O <=> chenodeoxycholic_acid + CoA + H+
|
3.1.2.2
palmitoyl-CoA hydrolase
3.1.2.20
acyl-CoA hydrolase
3.1.2.27
choloyl-CoA hydrolase
|
–
–
–
|
K
|
| |
BRENDA:
BS360780
KEGG:
R03974
MetaCyc:
RXN-14289
SABIO-RK:
13309
|
|
|
|
chenodeoxycholic_acid + NADP+ <=> 7-ketolithocholic_acid + NADPH
|
1.1.1.146
11beta-hydroxysteroid dehydrogenase
1.1.1.159
7alpha-hydroxysteroid dehydrogenase
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
–
–
|
|
| |
BRENDA:
BS187367
SABIO-RK:
9897
|
|
|
|
chenodeoxycholic_acid + FADH2 <=> lithocholic_acid + FAD + H2O
|
not assigned
|
–
|
|
| |
KEGG:
R03978
|
|
|
|
UDP-galactose + chenodeoxycholic_acid <=> beta-D-galactosyl-chenodeoxycholate + UDP
|
2.4.1.M19
|
–
|
|
| |
MetaCyc:
RXN-18316
|
|
|
|
chenodeoxycholic_acid + H+ <=> chenodeoxycholic_acid + H+
|
not assigned
|
–
|
|
| |
MetaCyc:
TRANS-RXN0-592
|
|
|
|
chenodeoxycholic_acid + reduced_flavodoxin + O2 <=> hyodeoxycholic_acid + flavin + H2O
|
1.14.14.57
taurochenodeoxycholate 6alpha-hydroxylase
|
–
|
|
| |
BRENDA:
BS443284
|
|
|
|
UDP-glucuronate + chenodeoxycholic_acid <=> UDP + chenodeoxycholic_acid_24-beta-D-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS436010
|
|
|
|
UDP-glucuronate + chenodeoxycholic_acid <=> UDP + hyodeoxycholic_acid_6-O-glucuronoside
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS399065
|
|
|
|
chenodeoxycholic_acid + UDP-glucuronate <=> UDP + chenodeoxycholic_acid_24-acyl-beta-D-glucuronide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS455458
|
|
|
|
chenodeoxycholic_acid + NAD+ <=> 7alpha,12alpha-dihydroxy-5beta-cholan-3-one-24-oic_acid + NADH
|
1.1.1.50
3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
|
–
|
|
| |
BRENDA:
BS372673
|
|
|
|
chenodeoxycholic_acid + NADPH + H+ <=> ursodeoxycholate + NADP+
|
1.1.1.201
7beta-hydroxysteroid dehydrogenase (NADP+)
|
–
|
|
| |
BRENDA:
BS438281
|
|
|
|
chenodeoxycholic_acid + NADP+ <=> (5beta,7alpha,8xi)-7-hydroxy-3-oxocholan-24-oic_acid + NADPH + H+
|
1.1.1.357
3alpha-hydroxysteroid 3-dehydrogenase
|
–
|
|
| |
BRENDA:
BS426095
|
|
|
|
3''-phosphoadenylyl-sulfate + chenodeoxycholic_acid <=> adenosine_3'',5''-bisphosphate + chenodeoxycholate_7-sulfate
|
2.8.2.14
bile-salt sulfotransferase
|
–
|
|
| |
BRENDA:
BS360187
|
|
|
|
3''-phosphoadenylyl_5''-phosphosulfate + chenodeoxycholic_acid <=> adenosine_3'',5''-bisphosphate + lithocholate_sulfate
|
2.8.2.34
glycochenodeoxycholate sulfotransferase
|
–
|
|
| |
BRENDA:
BS375746
|
|
|
|
Chenodeoxycholic_acid_3-O-beta-D-glucuronide + H2O <=> chenodeoxycholic_acid + D-glucuronate
|
3.2.1.128
glycyrrhizin hydrolase
|
–
|
|
| |
BRENDA:
BS361216
|
|
|
|
3alpha,7alpha-dihydroxy-5beta-cholanoyl-beta-Ala + H2O <=> chenodeoxycholic_acid + beta-Alanine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS140410
|
|
|
|
3alpha,7alpha-dihydroxy-5beta-cholanoylsarcosine + H2O <=> chenodeoxycholic_acid + sarcosine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS140413
|
|
|
|
ATP + H2O + chenodeoxycholic_acid <=> ADP + phosphate + chenodeoxycholic_acid
|
7.6.2.2
ABC-type xenobiotic transporter
|
–
|
|
| |
BRENDA:
BS444971
|
|
|
|
3alpha,7alpha-dihydroxy-5beta-cholanoyl-alpha-aminomethanesulfonic_acid + H2O <=> chenodeoxycholic_acid + aminomethanesulfonic_acid
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS140412
|
|
|
|
3alpha,7alpha-dihydroxy-5beta-cholanoyl-DL-Ala + H2O <=> chenodeoxycholic_acid + DL-alanine
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS140411
|
|
|
|
lithocholoyl-CoA + chenodeoxycholic_acid <=> lithocholic_acid + chenodeoxycholoyl-CoA
|
2.8.3.25
bile acid CoA-transferase
|
–
|
|
| |
BRENDA:
BS437675
|
|
|
|
chenodeoxycholic_acid + UDP-D-galacturonate <=> UDP + chenodeoxycholic_acid_O-galacturonide
|
2.4.1.17
glucuronosyltransferase
|
–
|
|
| |
BRENDA:
BS322218
|
|
|
|
taurochenodeoxycholate + H2O <=> chenodeoxycholic_acid + taurin
|
3.5.1.24
choloylglycine hydrolase
|
–
|
|
| |
BRENDA:
BS367828
|
|
